Porphyromonas gingivalisdecreases osteoblast proliferation through IL-6-RANKL/OPG and MMP-9/TIMPs pathways
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چکیده
منابع مشابه
Signaling pathways governing osteoblast proliferation, differentiation and function.
Osteoblasts are bone forming cells that are responsible for bone growth and remodeling. They are derived from bone marrow mesenchymal stem cells through a series of processes including commitment, osteoprogenitor expansion, terminal differentiation and cell death. Osteoblastogenesis and bone formation are regulated by hormones, growth factors, cytokines, mechanical loading and aging. Osteoblast...
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Stress cytokines tumor necrosis factor α, interleukin-1 β and interleukin-6 modulate the activity of a variety of cell types including osteoblasts, and are involved in the pathogenesis of several rheumatic diseases associated with systemic bone loss. We have studied the expression of interleukin-6 induced by interleukin-1 β and tumor necrosis factor α in the osteoblast-like cell line MG-63, der...
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ژورنال
عنوان ژورنال: Indian Journal of Dental Research
سال: 2009
ISSN: 0970-9290
DOI: 10.4103/0970-9290.52884